In turn this results in severe liver disease, such as alcoholic liver disease, nonalcoholic steatohepatitis and hepatocellular carcinoma (HCC; Cichoz‐Lach & Michalak, 2014) Recently, we reported that hCdHs were reprogrammed to bi‐potential progenitor cells from the hepatocytes by using small molecules, A83‐01 and CHIR99021 including HGF (Kim et al., 2019). Here, HGF is linked to metabolic dysfunction-associated steatohepatitis.