In turn this results in severe liver disease, such as alcoholic liver disease, nonalcoholic steatohepatitis and hepatocellular carcinoma (HCC; Cichoz‐Lach & Michalak, 2014) Recently, we reported that hCdHs were reprogrammed to bi‐potential progenitor cells from the hepatocytes by using small molecules, A83‐01 and CHIR99021 including HGF (Kim et al., 2019). The gene discussed is HGF; the disease is liver disorder.