Polymorphic variants in the PTEN (rs2735343),PI3K (rs2699887), AKT1 (rs2494750),AR (rs17302090), and AMACR (rs3195676)genes were evaluated as possible molecular markers of susceptibility, prognosis,and progression of prostate cancer (PCa), in a case-control study. This evidence concerns the gene AKT1 and prostate cancer.