None of the inhibitors, however, inhibits Pgp activity in KB-V1 cells, where the RI for both of them was found to be more than 3 (3.02 and 4.30 for zinc pyrithione and AUY922, respectively) suggesting that higher levels of Pgp expression in these cervical cancer cells may be responsible for this resistance (Fig 1A). The gene discussed is PGP; the disease is cervical carcinoma.