In breast cancer cases (n = 941) derived from three GEP datasets, three consensus gene sets were enriched according to TRPM4 expression in all three GEP datasets (i. e. GSE54002 n = 417, GSE20685 n = 327, and GSE23720 n = 197) as follows: (1) Estrogen Response Early (Hallmark ID: M5906) gene set containing genes involved in early response to estrogen; (2) Estrogen Response Late (Hallmark ID: M5907) gene set containing genes involved in late response to estrogen; (3) Epithelial-Mesenchymal Transition (Hallmark ID: M5930) gene set containing genes involved in EMT (Fig 6). The gene discussed is TRPM4; the disease is breast cancer.