TRPM4 and colorectal cancer: Knockdown of TRPM4 correlated with reduction of mesenchymal markers including N-cadherin and vimentin, while expression of epithelial markers was increased such as E-cadherin and Snail [20, 21]; (2) In colorectal cancer, tumor budding is characterized by presence of disseminated colorectal cancer cells driven by EMT for metastasis [52–54].