The top five KEGG pathways for the DEGs upregulated in osteoporotic patients were “cancer pathway,” “small cell lung cancer pathway,” “p53 signaling pathway,” “Wnt signaling pathway,” and “rap1 signaling pathway.” The top five KEGG pathways for the DEGs downregulated in osteoporotic patients were “axon guidance pathway,” “bacterial invasion of epithelial cells pathway,” “African trypanosomiasis pathway,” “Alzheimer's disease pathway,” and “calcium signaling pathway” (Table 2 and Figure 2). Here, TP53 is linked to early-onset autosomal dominant Alzheimer disease.