This is not entirely surprising given previous studies have failed to report consistent changes in LRP1 in AD brain tissue, with some showing no change (Causevic, Ramoz, Haroutunian, Davis, & Buxbaum, 2003; Provias & Jeynes, 2014) and others showing increases (Matsui et al., 2007; Qiu, Strickland, Hyman, & Rebeck, 2001) or decreases (Kang et al., 2000) compared to controls. The gene discussed is LRP1; the disease is Alzheimer disease.