Interestingly, a combined genetic association between tau and LRP1 polymorphisms has previously been associated with a sixfold increased risk for AD, possibly via the alteration of intracellular cholesterol levels and tau phosphorylation (Vázquez‐Higuera et al., 2009), although we did not identify any association between LRP1 and tau in the present study. This evidence concerns the gene LRP1 and Alzheimer disease.