LRP1 and Alzheimer disease: Two previous studies (Sánchez‐Guerra et al., 2001; Vázquez‐Higuera et al., 2011) have also failed to detect an association between single LRP1 or tau polymorphisms and AD, although the observation of reduced neurofibrillary tangle burden in statin‐treated AD patients postmortem (Li et al., 2007) suggests the relationship between tau and cholesterol pathways warrants further research.