Indeed, RAP deficiency increases Aβ deposition in murine transgenic models of AD (Xu et al., 2008) and reduces Aβ clearance (Van Uden et al., 2002), and a previous immunohistochemical study has demonstrated decreased RAP immunohistochemistry in AD brain tissue (John Provias & Jeynes, 2010). Here, LRPAP1 is linked to Alzheimer disease.