PIEZO1 and escherichia coli infection: Therefore its shear stress regulation via Piezo1 may be broadly relevant, for example in adherens junction biology and cartilage integrity, where functional importance of Piezo1 is already suggested (Friedrich et al., 2019; Lee et al., 2014), and amyloid plaque formation, where Piezo1 was originally detected (Satoh et al., 2006) and has been suggested to have functional importance in combination with E coli infection (Velasco-Estevez et al., 2018).