Topical dithranol application strongly reduced psoriatic lesions as measured by macroscopic overall ear thickness and microscopic epidermal thickness in this genetic model of psoriasis based on inducible epidermal deletion of the AP1 transcription factors c-Jun/JunB (Glitzner et al., 2014; Zenz et al., 2005; Figure 3B–D). Here, JUN is linked to psoriasis.