However, in contrast to CD9 ablation, which only causes complete infertility when combined with CD81 deficiency (Rubinstein et al., 2006), TMEM95 ablation alone completely blocks gamete fusion and thus, subsequent sperm entry into the ooplasm without generating any obvious structural defect in the sperm, thereby suggesting that TMEM95 may not play a major architectural role. The gene discussed is CD9; the disease is Infertility.