SFRP1 and renal fibrosis: Therefore, the present work aimed to assess the expression levels of miR-27a, Sfrp1, and Wnt/β-catenin signalling-related molecules in vitro and in vivo to investigate whether miR-27a can cause renal fibrosis by regulating Sfrp1 and activating Wnt/β-catenin signalling in high-glucose-treated renal tubular epithelial cells.