TNF and familial pancreatic carcinoma: Götschel et al. (2008) documented that the inhibition of GSK3β reduced nuclear factor κB (NF-κB) activity and attenuated TNF-α mediated apoptosis in hepatocytes (Götschel et al., 2008). Moreover, glycogen synthase kinase-3β participates in cell survival in pancreatic cancer cells (Ougolkov, Fernandez-Zapico, Savoy, Urrutia, & Billadeau, 2005).