The immunohistochemical analysis showed that the levels of PD-L1 and p-STAT3 (Tyr705) were increased, while that of PARP1 was decreased in tumor tissue samples from mice treated with ODN1585 alone or in combination with an anti-PD-1 antibody (Figure 5A-B, Figure S4A). The gene discussed is CD274; the disease is neoplasm.