Moreover, the introduction of a functional mutant STIM1 with a deletion of the C-terminal domain (STIM1-ΔCTD) failed to reverse anoikis resistance caused by STIM1 deficiency (Figure 2D-F), suggesting that repressed SOCE may contribute to anoikis resistance in STIM1 KO-HCC cells. Here, STIM1 is linked to hepatocellular carcinoma.