SNAI1 and hepatocellular carcinoma: Besides, the Snail1 protein expression was reduced in STIM1 KO-HCC cells, while Snail1 restoration couldn't reverse the expression changes of metabolic enzymes triggered by STIM1 deletion (Figure 6A), suggesting that the switched metabolism from aerobic glycolysis towards FAO after depletion of STIM1 is in a Snail1-independent manner.