Our data revealed that ALDH1A1 and ALDH1A3 mRNA expression positively correlates with c-MYC gene expression in the neuroblastoma patient samples, and siRNA-mediated c-MYC knockdown inhibited expression of ALDH1A2 and ALDH1A3 genes in the MYCN-amplified neuroblastoma cells. The gene discussed is ALDH1A1; the disease is neuroblastoma.