Importantly, we observed that the proportion of mature neurons (% NeuN+ over total EdU+ cells) was significantly reduced and the percentage of EdU labelled DCX-, NeuN- NPCs (% DCX-/NeuN- over BrdU+ cells) was increased in 3xTg-AD mice (Figure 2E, 2G). The gene discussed is RBFOX3; the disease is Alzheimer disease.