MGLL and Alzheimer disease: Thus, these results support that aging-dependent induction of Mgll expression in the AD hippocampi is associated with a reduction of aPKC expression/activity, and that Mgll levels are upregulated following the attenuation of the aPKC-CBP pathway in phospho-null CbpS436 knock-in mice during healthy aging, the activation of which sustains hippocampal neuronal differentiation and spatial memory 8.