Furthermore, the presence of oxidatively-truncated lipids has been shown to interfere with major histocompatibility complex (MHC)-mediated antigen cross-presentation by dendritic cells in cancer 158, and alterations of the membrane lipid composition, specifically increased PUFA content, have been shown to negatively affect antigen presentation and modulate the inflammatory eicosanoid metabolites 159, suggesting decreased immunogenicity of cancer persister cells. The gene discussed is HLA-C; the disease is cancer.