Just as LncRNA GAS5 inhibiting apoptosis of SMC to become a strategy against abdominal aortic aneurysm (AAA) 57 and miR-27a targeting apoptosis of ECs and strongly diminishing occurrence of aortic dissection (AD) 58, Stabilizing Kindlin-2 might potentially serve as a novel strategy against CIPO. This evidence concerns the gene GAS5 and Aortic dissection.