NFKBIA and cardiac hypertrophy: The activation of NF-κB has been found to be necessary for pathological hypertrophy in vitro and suppression of the activation of NF-κB by using cardiac specific expression of a mutant IκBa super-repressor mice could attenuate cardiac hypertrophy induced by AngII-and ISO-infusion, or low-grade aortic banding 48,49.