Although the coexpression of ARID3B and HES1 did not have a significant impact on the overall survival in all patients (Figure S3C), a subgroup analysis demonstrated the prognostic impact of the coexpression of ARID3B and HES1 in stage IV CRC patients (the 3-year survival rates, 15.4% vs. 35.0%, p = 0.019) (Figure 3E). Here, HES1 is linked to colorectal carcinoma.