We first screened the effect of different inhibitors, including a canonical Notch pathway inhibitor (DAPT), Wnt pathway inhibitor (IWR1), KDM4C inhibitor (SD70), and KDM4A/B inhibitor (NSC636819), on suppressing the proliferation of ARID3B-overexpressing CRC cells. The gene discussed is ARID3B; the disease is colorectal carcinoma.