ARID3B recruits KDM4C for histone modification of target genes. Because ARID3B binds to the regulatory region of Notch target genes through an NICD-independent mechanism in CRC cells (Figure 4), we examined whether ARID3B regulates Notch target genes through other known NICD/CBF1-independent pathways, such as β-catenin 59, GLI2 60, and phospho-JNK 61. The gene discussed is NOTCH1; the disease is colorectal carcinoma.