qPCR analysis revealed that CREB1 expression was significantly upregulated in CRC liver metastatic tissues and primary tumor tissues compared to matched adjacent normal tissues (Figure 5B), and the expression of CREB1 was tightly correlated with the expression of ARHGAP5 in CRC samples available from SYSUCC (n=78) (Figure 5C). This evidence concerns the gene CREB1 and neoplasm.