A previous study showed that ARHGAP5 was upregulated by the amplification of the chromosomal region 14q12 in a subgroup of hepatocellular carcinoma 40, by downregulation of miR-486-5p or miR-774 in lung cancer and nasopharyngeal carcinoma respectively 39, 43. This evidence concerns the gene ARHGAP5 and lung carcinoma.