In the significantly upregulated transcripts, our data showed that only in IL-22-treated groups, but not control groups, an obvious enrichment of upregulated pathways associated with glycolysis, AMPK signaling pathway, nicotinate and nicotinamide metabolism, and choline metabolism in cancer was present in addition to expected processes (e.g., fat digestion and absorption, and central carbon metabolism in cancer; Figure 2B-D and Figure S3). Here, IL22 is linked to cancer.