Notably, MDL-811-induced deacetylation of H3K9Ac, H3K18Ac, and H3K56Ac in HCT116, HT29, and SW480 cells was significantly stronger than that in other cell lines (Figure 2B and Figure S4B), consistent with the higher protein levels of SIRT6 in these three cell lines (Figure 2E) and supporting a positive association between the action of MDL-811 and the protein level of SIRT6 in CRC cells. This evidence concerns the gene SIRT6 and colorectal carcinoma.