Though the role of SIRT6 in cancers is cell-context dependent, and SIRT6 plays an oncogenic role in some cancers, such as skin cancer, squamous cell carcinoma, prostate cancer, and acute myeloid leukemia 16-20, SIRT6 acts as a tumor suppressor in multiple cancers including CRC and could be a potential epigenetic drug target for CRC treatment. This evidence concerns the gene SIRT6 and squamous cell carcinoma.