SIRT6 and colorectal carcinoma: Further analysis revealed that the IC50 values of MDL-811 in the CRC cell lines negatively correlated with not only the protein levels of SIRT6 (Pearson correlation, r = -0.7939, P = 0.0020, n = 12) (Figure 2E) but also the deacetylation of H3K9Ac (r = -0.4734, P = 0.0146, n = 26) and H3K56Ac (r = -0.4631, P = 0.0172, n = 26) after treatment with MDL-811 (Figure S4D).