CYP24A1 and colorectal carcinoma: Indeed, previous studies have shown that CYP24A1 inhibition markedly increases the anti-tumor activity of 1,25(OH)2D3 in CRC cells 59, 60, suggesting that inhibition of CYP24A1 transcription by MDL-811 may enhance the efficacy of 1,25(OH)2D3 for CRC treatment.