MDL-811 increased the thermal stability of SIRT6, with an increase in the melting temperature from 45.8 °C to 47.6 °C (ΔTm = 1.8 ± 0.2 °C) (Figure S4A and Table S3), indicating that MDL-811 can bind and stabilize its target, SIRT6, in CRC cells. The gene discussed is SIRT6; the disease is colorectal carcinoma.