In response to glucose deprivation, JMJD2B promotes autophagy to produce three intracellular amino acids (Asn, His and Phe), which could promote the survival of CRC cells through epigenetic regulation of LC3B. Our results may provide a better understanding of the molecular mechanism leading to CRC, and identify JMJD2B as a potential target for CRC treatment. This evidence concerns the gene MAP1LC3B and colorectal carcinoma.