JMJD2B activated autophagy via epigenetic regulation of LC3B; therefore, we next examined whether LC3B participated in JMJD2B-mediated alteration of amino acids and promotion of tumorigenesis, using an LC3B overexpression plasmid transfected into JMJD2B-knockdown CRC cells. This evidence concerns the gene KDM4B and colorectal carcinoma.