IL6 and colitis: Although all the drugs tested, including anastrozole, berberine and pranoprofen, have been shown to alleviate inflammation in terms of final colon length, inflammatory cell infiltration and cell apoptosis in colon tissues, and serum IL-6 levels, their effects on mouse body weight were different, i.e., anastrozole prevented colitis-induced body weight loss, while berberine and pranoprofen had minimal effects on colitis-induced body weight loss (Figure 6C and Figure S16C, S17A, S18A).