To further confirm whether CCL2 and CXCL5 function as pivotal chemokines mediating S100A14-induced breast cancer metastasis in vivo, we used the 4T1 orthotopic transplantation model in which mice were treated with CCL2- and CXCL5-neutralizing antibodies or IgG control antibodies. The gene discussed is CCL2; the disease is breast carcinoma.