METTL3 and hepatocellular carcinoma: As such, Mettl3-WT- and Mettl3-KR-expressing cells were harvested, and their cell lysates were subjected to co-immunoprecipitation with anti-Mettl3 or control IgG antibody, followed by western blotting with indicated antibodies (Figure 5F), The results revealed that SUMOylation of Mettl3 did not influence the translation initiation factors and translation elongation factors, suggesting that Mettl3 SUMOylation did not regulate HCC cell translation efficiency.