Since SUMOylation-deficient Mettl3 limited Snail accumulation, Snail expression was increased in the Mettl3-KR mutant-expressing group, which showed that Snail overexpression antagonized the suppression of wound healing through Mettl3 SUMOylation deficiency in liver cancer cells (Figure 4G). The gene discussed is SNAI1; the disease is liver cancer.