Since SUMOylation-deficient Mettl3 limited Snail accumulation, Snail expression was increased in the Mettl3-KR mutant-expressing group, which showed that Snail overexpression antagonized the suppression of wound healing through Mettl3 SUMOylation deficiency in liver cancer cells (Figure 4G). This evidence concerns the gene METTL3 and liver cancer.