Moreover, hepatocyte growth factor (HGF), a known mitogenic signal associated with invasive program and metastasis during tumor progression in HCC, was included as another mitogen to stimulate cells, and the mitogen-response SUMO-conjugated Mettl3 was examined by immunoprecipitation with anti-Mettl3 specific antibody. The gene discussed is METTL3; the disease is hepatocellular carcinoma.