This, therefore, suggests an indirect protective role by FGF21in the amelioration of HE through the stimulation of signal transducer and activator of transcription 3 (STAT3) signaling pathway similar to that of recombinant IL-22 treatment in liver injury and alcoholic fatty liver (Kong et al., 2013[22]). The gene discussed is STAT3; the disease is hereditary elliptocytosis.