The ECM in liver fibrosis is maintained by transforming growth factor β1 (TGF-β1) by enhancing the activation of fibroblasts and HSCs while inhibiting apoptosis of fibronectin, collagen (Col) types I and III, tenascin, elastin and osteonectin, the factors involved in liver fibrogenesis (Karin et al., 2016[21]). Here, TNC is linked to Hepatic fibrosis.