CASP3 and hepatocellular carcinoma: On the other hand, Fei et al. showed that perifosine caused activation for caspase-3, caspase-9 and Poly ADP Ribose Polymerase (caspase downstream effector, PARP) in human hepatocellular carcinoma cells (HepG2), but did not affect P53 and BCL2 levels (Fei et al., 2010[10]).