Elrod et al. indicated that perifosine (8 to 15 μmol/L) induced expression of death receptor 5 (DR5) in human non–small cell lung cancer (NSCLC) cell lines (H157 and A549), decreased FLICE-inhibiting protein (c-FLIP) and BAX expression levels, but had a limited modulatory effect on BCL2, Bcl-XL and p53 upregulated modulator of apoptosis (PUMA) levels (Elrod et al., 2007[8]). This evidence concerns the gene BBC3 and lung cancer.