AKT1 and acute lymphoblastic leukemia: Pistor et al. showed that methylprednisolone (2.5 mM), vitamin D (100 nM) and MK-2206 (AKT inhibitor, 2 μM) have a synergistic effect on apoptosis of steroid-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells (Pistor et al., 2018[30]).