Previous work characterizing mouse models with excitatory-neuron specific gene ablation via CamKII-Cre found that conditional Kmt2a deletion led to clear learning deficits20, while cognitive impairments in the conditional Kdm5c-KO mice were much milder than those of constitutive Kdm5c-KO mice22. This evidence concerns the gene KDM5C and Cognitive impairment.