In 2 such biopsies with readily detectable EBER-positive reactive lymphocytes (n = 1 reactive lymphadenitits; n = 1 cHL—Supplementary Fig. 2), RNAscope for EBNA1 consistently produced an intense staining (homogeneous or comprising multiple dots) in small reactive lymphoid cells (presumably in EBV latency I, i.e., expressing not only EBER but also EBNA1 [5, 6, 37]) or in activated germinal center B cells (presumably in latency II, i.e., expressing not only EBER and EBNA1 but also LMP1 [38]. This evidence concerns the gene PDLIM7 and classic Hodgkin lymphoma.