NF1 and melanoma: Hodis et al. reported that, out of 121 melanomas, seven cases had MAP2K1 mutations, composed of point mutations and a single in-frame deletion; while four co-occurred with BRAF mutation, one co-occurred with NRAS mutation, and two occurred independently of BRAF, NRAS, and NF1 mutation, co-mutations were not specified by MAP2K1 mutation type [12].