IFIT1 and rheumatoid arthritis: However, the profiles of other IFN response genes tested displayed a more disease-specific pattern such that IFIT1 only reached statistical significance in RA (x 1.93 FC, p = 0.00435) and UA (x 1.98 FC, p = 0.0180) and significant levels of SIGLEC1 (x 2.28 FC, p = 0.00597) and MS4A4A (x 2.19 FC, p = 0.00000904) were restricted to the RA cohort (Fig. 3 and Table 4).