PARP1, located in the Chr1q42.1 melanoma locus8, was shown to be a susceptibility gene that has tumor-promoting roles in early events of melanomagenesis through its regulation of melanocyte master transcription factor and oncogene, MITF18, while a functional variant at a multi-cancer locus on Chr5p15.33 was characterized highlighting the role of TERT in cancer susceptibility including in melanoma19. The gene discussed is PARP1; the disease is melanoma.