The results demonstrated that zebrafish with transgenic human MX2 expression presented an accelerated melanoma formation (46% of fish developed melanoma by 19 weeks; n = 184) compared to those with GFP controls (33% of fish by 19 weeks; n = 194) in this genetic background (P = 0.003; log-rank test; Fig. 6e, f). The gene discussed is MX2; the disease is melanoma.