Nevertheless, our findings established MX2 as a gene displaying pleiotropic roles in melanoma susceptibility and immune response, building on to the established roles of telomere biology (TERT, Chr5p15.33)19 and oncogene-induced senescence (PARP1, Chr1q42.1)18 in genetic susceptibility to melanoma in the general population. The gene discussed is PARP1; the disease is melanoma.