Among 20 genome-wide significant melanoma loci from the most recent GWAS meta-analysis1, we prioritized 16 loci where a potential cis-regulatory mechanism could be hypothesized, excluding four pigmentation-associated loci previously explained by functional protein coding variants (MC1R, SLC45A2, and TYR11–14) or shown not to be expressed in melanocytes (ASIP15). Here, MC1R is linked to melanoma.