CBFA2T3 and leukemia: We experimentally proved GLIS family zinc finger 2 (GLIS2) as a repressor for p53 target apoptotic gene PUMA. GLIS2 has been proposed as an oncogenic gene in leukemia, caused by the fusion of GLIS2 with CBFA2T3 which led to GLIS2 overexpression20–22.