It localizes on mouse chromosome 11, in the intervening region of Myo1g (Myosin IG) and Ccm2 (Cerebral cavernous malformation 2) protein-coding genes (Fig. 1b), with well-defined gene structure and a binding peak of myogenic master transcription factor, MyoD on its promoter region (Fig. 1a). Here, CCM2 is linked to famililal cerebral cavernous malformations.