Taking advantage of high infection levels in HepG2-NTCP cells, we aimed to confirm the phenotypic effect of CDKN2C on HBV infection by a loss-of-function approach, using small interfering RNA (siRNA) specifically targeting CDKN2C or SLC10A1 (the gene encoding the HBV receptor NTCP) in susceptible HepG2-NTCP cells, as shown in Fig. 4b, c. This evidence concerns the gene SLC10A1 and infection.