Post stimulation, the T1D subjects showed a significantly higher frequency of pDCs expressing CD80 (68.33 ± 6.19% vs 39.77 ± 6.3%) (p = 0.01), CD86 (75.62 ± 4.06% vs 50.26 ± 7.0%) (p = 0.04) and co-expressing CD80 and CD86 (49.9 ± 5.9% vs 28.4 ± 4.6%) (p = 0.04) than their HC counterparts (Fig. 6 a,c,e). This evidence concerns the gene CD80 and type 1 diabetes mellitus.