CDKN2A and melanoma: <h4>Background</h4>Pathogenic variants in the <i>CDKN2A</i> gene are generally associated with the development of melanoma and pancreatic ductal adenocarcinoma (PDAC), but specific genotype-phenotype correlations might exist and the extent of PDAC risk is not well established for many variants.<h4>Methods</h4>Using the Dutch national familial melanoma database, we identified all families with a pathogenic <i>CDKN2A</i> variant and investigated the occurrence of PDAC within these families.