Using GWAS or local sequence alignment techniques, microtia was reported to be associated with mutations in GATA6 (GATA binding protein 6) in Awassi sheep [3], DCC (deleted in colorectal carcinoma) in Duolang sheep [4], CLRN1 (Clarin 1) in Valle del Belice [5] and a duplication within an evolutionary conserved region (ECR) near HMX1 (H6 family home-box 1) in Altay sheep [6]. The gene discussed is CLRN1; the disease is colorectal carcinoma.