In an earlier study, we showed that in unstimulated GCB DLBCL cells, SYK is primarily phosphorylated on the regulatory tyrosine (Y) at position 352, whereas phosphorylation of the regulatory tyrosines at 525/526 becomes mainly detectable following BCR crosslinking with an external ligand [95]. The gene discussed is SYK; the disease is diffuse large B-cell lymphoma.