The BCR dependency of these GCB DLBCL lines was not detected in the initial RNA interference screens that revealed the BCR-dependence of the ABC DLBCL cell lines [87], presumably because of the incomplete knockdown of BCR subunits with this technique, but was confirmed more recently using a CRISPR/Cas9 genome editing approach [97]. The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.