The mutations of VCP are found to be associated with some human degenerative disorders, such as amyotrophic lateral sclerosis (ALS), inclusion body myopathy (IBM) associated with Paget disease of the bone (PDB), and frontotemporal dementia (FTD), also called IBMPFD, which mainly affect the brain and muscles [12]. The gene discussed is VCP; the disease is inclusion body myopathy with Paget disease of bone and frontotemporal dementia.