The mutations of VCP have been associated with diverse myodegenerative and neurodegenerative disorders including inclusion body myopathy (IBM), with Paget disease of the bone, as well as frontotemporal dementia (IBMPFD) and amyotrophic lateral sclerosis (ALS). The gene discussed is VCP; the disease is inclusion body myopathy with Paget disease of bone and frontotemporal dementia.