In mammals, the Hippo pathway proteins mammalian Ste20-like (MST) and large tumor suppressor (LATS) suppress the transcriptional co-activators yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which interact with TEA domain family member (TEAD) to regulate expression of genes that control proliferation, survival, differentiation, and also cancer development [11]. The gene discussed is YAP1; the disease is cancer.