BRAF and colorectal carcinoma: RAS mutations, which are commonly found in tubular and tubulovillous adenoma, are rare genetic abnormalities in SSA/P, whereas CpG island methylator phenotype positive (MLH1 negative), microsatellite instability status, and BRAF mutations are known as common gene profiles of SSA/P [6], which is emphasized in the progression to CRC along with DNA mismatch repair gene abnormalities [7].