The above results indicated that, at 96 h p.i., multiple host proteins were differentially regulated between Han and HanUL138del in infected MRC5 cells, and among these proteins, BORCS7, FAM172A, RELL1, and WDR48 can promote HCMV infection, while STEAP3 can inhibit HCMV replication. Here, WDR48 is linked to cytomegalovirus infection.