Moreover, it was shown that the pathological activation of MMP-1 by the enhanced entrance of Ca2+ through a mutant TRPV4 with a gain-of-function mutation (TRPV4-P19S) [124] present in a population of humans, could play an important role in chronic obstructive pulmonary disease exhibited by individuals with this genetic polymorphism [126]. This evidence concerns the gene TRPV4 and chronic obstructive pulmonary disease.