It has also been demonstrated that, in vitro and in vivo, TRPV4 is constitutively a part of the signaling pathways of cytosolic phospholipase A2 (cPLA2α), MAP-kinases, and NF-κB, supporting its involvement in the inflammatory response and potentially in cystic fibrosis pathogenesis [128]. This evidence concerns the gene TRPV4 and cystic fibrosis.