TGFB1 and asthma: For example, in an asthma mice model, TRPV4 activation in the membrane promotes an increase in transforming growth factor- beta 1 (TGF-β1) through a signaling pathway involving PI3K and leads to stimulation of the myocardin-related transcription factor A (MRTF-A), which depends on Rho/myocardin.