Unexpectedly, experimental models of CKD associated with oxidative stress present with reduced Nrf2 activity and expression of its target gene products in kidney tissues, but the administration of the Nrf2 activator curcumin ameliorated CKD by blocking inflammatory pathways and inhibition of nuclear factor κB (NF-κB) [86,87,88,89,90]. This evidence concerns the gene NFE2L2 and chronic kidney disease.