A hallmark feature of obesity is adipose tissue expansion and altered adipocyte fatty acid-triacylglycerol metabolism [37], and when combined with the reports that the amount of PPAT correlates with higher grade or aggressiveness of disease (for review, see [13]), it is an attractive hypothesis that an adipose–PCa axis underpins these clinical observations in obese patients. The gene discussed is PPAT; the disease is obesity due to melanocortin 4 receptor deficiency.