The incretin effect resulting from targeting GLP-1R led to the successful commercialization of three short-acting agonists [exenatide, lixisenatide, and liraglutide] and three long-acting agonists [bydureon, dulaglutide, and semaglutide] as therapeutics for type 2 diabetes (T2D) [3]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.