We observed no reduction of tumor growth in Aldh1l1−/−; KrasLA2 mice, but treatment of these mice with phenformin decreased tumor growth by ~70% (Figure 5), consistent with the 70% reduction in NADH level when ALDH1L1-knockdown NSCLC cells are treated with phenformin [10]. The gene discussed is ALDH1L1; the disease is neoplasm.