U2AF1 and acute myeloid leukemia: Among these factors, SF3B1, SRSF2, and U2AF1, are most frequently mutated in patients with myelodysplastic syndrome (MDS), and also commonly occurred in clonal hematopoiesis, acute myeloid leukemia (AML), CLL, and a variety of solid tumors (Table 1) [18,19,20].