Interestingly, leukemia patients carrying dysfunctional NUDT15 who experience leukopenia are reported to have lower 6-TGN levels (maximum of 171 pmol/8 × 108 RBCs), which is far below the 450 pmol/8 × 108 RBCs concentration threshold [23,34]. Here, NUDT15 is linked to Decreased total leukocyte count.